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Are you Looking for YK-11 for sale? at our store, you can easily buy YK11 liquid. YK-11 is an investigational Myostatin Inhibitor and a SARM.
| Synonyms | YK-11 |
| Concentration | 10mg per ml |
| Solvent | USP Grade Polyethylene Glycol 400 |
| Molar Mass | 393.83 g·mol−1 |
| CAS | 1182367-47-0 |
| Chemical Formula | C20H16ClN5O2 |
This product is for laboratory research purposes only and is not approved by the FDA for human use. YK-11 is NOT a dietary supplement. Any information about its use in this product description refers to clinical research only. By ordering from this site, you agree to our terms of service.
SARMs in short, or Selective Androgen Receptor Modulators, are relatively new researched chemical substances. Among the most popular SARMs is a relatively new SARM called YK11, which acts as a gene-specific agonist of the androgen receptor (AR) in MDA-MB (453) cells. Interestingly enough, YK11 SARM works on a multitude of different anabolic pathways. In some studies[1,2], YK-11 has shown higher anabolic activity in vitro in C2C12 myoblasts than even DHT. YK11 also promoted a sequence chain of muscle growth and key myogenic regulatory factors in skeletal muscle tissue such as myogenic differentiation factor (MyoD), and myogenic factor 5 (Myf5), much more than DHT. maybe not so surprisingly, these anabolic effects can be seen as somewhat comparable to those of testosterone.
Unlike testosterone and most other AR anabolic agents, YK11's oral bioavailability is quite high meaning it is not administered by an injection for proper absorption. This can perhaps offer an explanation for why YK11 exerts its selective modulation of the AR.
In this article, we'll take a closer look at what YK11 is capable of and discuss some effects of its use. So read on to learn more!
YK-11 is often praised by researchers due to its interesting molecular activity in both the follistatin and the traditional androgen-mediated growth pathways. Finding YK-11 and other SARMs for sale online is fairly simple, there are more than enough vendors offering them online, but out our store, Sarmful.com we offer the best place to buy YK-11 online because of our proven and regularly consistent high-quality products and superb customer service and professional bottling and packaging practices. Our YK-11 is also available in pure powder form.
By choosing to buy SARMs at our store Sarmful.com you are investing in the highest quality ingredients, that means minimum 98% (and often higher) pure compounds tested and certified by accredited US third party labs- visit out tests page for more info.
More benefits:
These are just some of the reasons why we are certain regarding our ability to offer the best YK 11 for sale on the internet. For further questions about our Powder YK-11 or liquid YK11 products, you can also contact us directly, and we will get back to you in no time.
YK11 has been shown to promote muscle growth and prevent muscle wasting, making it a potentially valuable therapeutic agent for the treatment of various muscle-related disorders in animals.
While further research is needed to fully characterize the potential benefits of YK11, early findings suggest that this compound may hold significant promise for the treatment of a wide range of muscle-related conditions as the following explains further.
Uniquely enough, a key component of the YK-11 SARM's anabolic activity is modulated via the expression of follistatin, making it quite a special compound. This was discovered by co-administering anti-follistatin antibodies with YK-11 in order to measure the difference in effects [2]. Additionally, it has been demonstrated that follistatin promotes insulin-stimulated glucose and amino acid uptake right into the skeletal muscle cells, resulting in better insulin sensitivity and an increase of skeletal muscle mass [3]. Follistatin proteins also were shown to block inhibitory ligands from binding to Transforming Growth Factor-ß (TGF-ß) [4].
One of the most captivating effects of follistatin is its ability to bind and neutralize the catabolic proteins Activin A, Activin B, and Myostatin. Even when injected directly into a wasting muscle, follistatin proteins undergo rapid proteolysis and have a relatively low bioavailability and short half-life which are both undesirable profiles. Somewhat compensating for that, YK-11 however stimulates the body to produce higher levels of follistatin both overall and locally in the injection point which may promote muscle growth and combat wasting [2, 4].
Further studies conducted on animals have put to test the effects of YK-11 as a potential treatment for sepsis-induced muscle wasting. Scientists observed Yk-11-induced protective effects on organ and muscle tissue, as well as the overall suppression of inflammation induced by gram-negative bacteria. The longevity rate in eight-week-old septic mice treated with YK-11 also increased significantly. The researchers concluded this is due to the suppression of myostatin and an increase in the expression of the follistatin gene [5].
In a different study, a combination of DHT with YK11 was concluded to accelerate cell mineralization and proliferation in MC3T3-E1 mouse osteoblast cells. YK-11 treatment also provoked the expression of osteoblast-specific differentiation markers, these are osteocalcin and osteoprotegerin when compared to untreated cells [6]. The same study also showed that YK-11 also seems to activate non-genomic signaling via phosphorylation of AKT protein. This signaling pathway is established to be an important regulator of androgen-mediated osteoblast differentiation, making it an interesting compound for further research in the field of bone tissue improvements[6].
RAD140 is still a relatively new compound and has not been extensively studied. YK11, nonetheless, has been shown to be very effective in increasing muscle mass and strength in animal subjects. YK11 also appears to have fewer side effects than RAD140.
Since its discovery in 2009, YK11 has quickly become one of the most popular SARMs on the market. It is known for its ability to stimulate muscle growth and has been shown to be more potent than any other SARM.
Side effects of YK11 include a decrease in testosterone production, headaches, nausea, joint pain, hair loss, acne, low energy, and stomach issues. While these side effects have been reported, they are not guaranteed to occur with all users of YK11, as clinical studies revealed little regarding this.YK11 is approved for laboratory research purposes only and not for human consumption.
Like other SARMs, YK11 has a short half-life of only 12 hours. However, its effects are long-lasting.
There are a lot of common questions that come up about YK11 that we will address here.
There is some speculation that YK11 may suppress testosterone levels, but there is no concrete evidence to support this claim. More research is needed in order to determine the full effects of YK11 on subjects.
It takes about a week for YK11 to start working. This can vary dramatically depending on the way of usage.
There is very little information available on the safety of YK11. It is unclear what the long-term effects of using this research compound may be, and if there is a real risk of serious side effects. It is approved only for research purposes and not human consumption
There is no clear consensus on whether YK11 is a SARM. Some researchers classify it as one, while others argue that its properties differ significantly from traditional SARMs.
In any case, further research is needed to determine the full extent of YK11's effects and how it compares to other SARMs.
YK11 is made by altering the chemical structure of naturally occurring steroid hormones, the chief of which is DHT, which is a naturally occurring steroid hormone. YK11 works differently than other SARMs. In the case of YK11, it works in a different way, mainly because it does not have a nonsteroidal structure like other SARMs. This means that YK11 produces different outcomes and can have much different side effects.
Myostatin inhibitors are chemicals that suppress the production of myostatin in the cells. Myostatin is a protein that inhibits muscle growth.
YK-11 is a myostatin inhibitor that has been found to be one of the most effective on the market for promoting mass muscle growth and volume. It can also be used for achieving weight loss and better vascularity in test subjects.
Unfortunately, there is no definitive answer to this question as YK11 is an unregulated substance. Generally, SARMs are sold in various online supplement retailers for clinical use in animals or for research purposes. Sarmful.com is a proven vendor for this.
It's important to be aware that because of its unregulated status, the quality and safety of any YK11 products you may purchase cannot be guaranteed, therefore, you should only buy YK-11 from chemical research companies.
The legal status of YK11 is currently ambiguous. While it is legal for research purposes and testing in animals, it has not been approved for human consumption.
As a result, it is banned by the World Anti-Doping Agency (WADA). YK11 is considered a performance-enhancing drug and is not allowed in professional sports.
YK-11 Chemical Structure
YK-11 has one of the lowest solubilities out of any other SARM, it is only soluble in DMSO and Ethanol.
SARMs should only be used under the direct supervision and direction of a trained and licensed medical doctor or a designated research authority. Sarmful strongly discourages the use of SARMs for performance enhancement in fields of various sports such as bodybuilding and achievement sports, etc.
S4 is an investigational compound still undergoing research and NOT yet FDA approved, nor it is a dietary supplement. Sarmful is solely a research chemical supplier specializing in sourcing and quality control. We are not medical doctors. Sarmful discourages strongly against “bro science” and peer consensus when making decisions about human health.
We do not encourage or condone consumer use of SARMs products, they are for research purposes only.
1. Kanno Y, Hikosaka R, Zhang SY, Inoue Y, Nakahama T, Kato K, Yamaguchi A, Tominaga N, Kohra S, Arizono K, Inouye Y (2011). “(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor”. Biological & Pharmaceutical Bulletin. 34 (3): 318–23. PMID 21372378 https://pubmed.ncbi.nlm.nih.gov/21372378/
2. Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). “Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression”. Biological & Pharmaceutical Bulletin. 36 (9): 1460–5. PMID 23995658. https://pubmed.ncbi.nlm.nih.gov/23995658/
3. Han X, Moller LLV, et al. Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle. J Cachexia Sarcopenia Muscle. 2019 Aug 11. doi: 10.1002/jcsm.12474 https://pubmed.ncbi.nlm.nih.gov/31402604
4. Castonguay R, Lachey J, Wallner S, et al. Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle. J Pharmacol Exp Ther. 2019 Mar;368(3):435-445. doi: 10.1124/jpet.118.252304. Epub 2018 Dec 18. https://jpet.aspetjournals.org/content/jpet/368/3/435.full.pdf
5. Su Jin Lee, Amal Gharbi, Joo Eun Shin, In Duk Jung, Yeong Min Park, Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis, Biochemical and Biophysical Research
6. Yatsu T, Kusakabe T, Kato K, Inouye Y, Nemoto K, Kanno Y. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells. Biol Pharm Bull. 2018;41(3):394-398. doi: 10.1248/bpb.b17-00748. PMID: 29491216.
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