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MK677 (Ibutamoren)

An Investigation Oral Growth Hormone Secretagogue (Growth Hormone "Booster")

65.99

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  • Active Ingredient: MK677
  • Strength: 25/ml
  • Each Bottle Contains: 30ml

📄 Short Description

Are you Looking for MK677 for sale (Ibutamoren)? at our store, you can easily buy MK677 online. MK-677 is a oral (non-peptide) agonist of the Ghrelin receptor and a growth hormone secretagogue. It has been shown to increase the secretion of several hormones including GH and IGF-1.

✅ 3rd-Party Lab Tests  

Lab test date: 27/04/2024
Lab: Colmaric Analyticals
Speficiation: >98%
Result: 123%

Data on our MK677 for Sale

Synonyms MK-677, Ibutamoren,Oratrope
Concentration 25mg per ml
Solvent USP Grade Polyethylene Glycol 400
Molar Mass 528.67 g·mol−1
CAS 159634-47-6
Chemical Formula C27H36N4O5S

This product is for laboratory research purposes only and is not approved by the FDA for human use. MK677 is NOT a dietary supplement. Any information about its use in this product description refers to clinical research only. By ordering from this site, you agree to our terms of service.

Information About Our MK677 (Ibutamoren)

MK 677 (Ibutamoren), is a ghrelin agonist that acts on the pituitary gland as a human growth hormone secretagogue. This means that it stimulates the subject's body to produce more growth hormones. it is also sometimes classified along with other  SARMs. although it differs from Ghrelin itself as it is not a peptide but rather a spiropiperidine, which means it can cross the blood-brain barrier. It is known that MK-677 has an advantage over compounds like GHRP-2 and GHRP-6  in that it boosts IGF-1 levels for 24 hours after a single dose without restricting natural pulsatile growth hormone release. Since it does not exert its effect via the common androgen receptor like Testosterone or other anabolic compounds, it is believed that MK677 may improve body composition without negatively impacting endogenous androgen secretion. It is safe to say that MK677 is of a long line of new compounds that are generating a buzz of conversation as research continues. due to the increase of successful lab work made on animals and its associated positive findings, MK-677 is now available for sale as a medical research compound as detailed below.

When given to subjects orally, MK 677 (Ibutamoren) mimics fasting and the action of the hunger-related hormone called ghrelin. This in turn increases growth hormones (GHs) release in the body [3]. It is powerfully effective in boosting levels of insulin-like growth factor 1 (IGF-1) which is related to various health benefits. MK 677's oral bioavailability is quite high so it does not require injection for proper absorption, unlike other growth hormone-increasing peptides.

More precisely, according to research, Mk 677 can result in and cause, higher Growth hormone levels and reverse their deficiency [1], improving bone density and muscle growth [2,4], mitigating symptoms of the natural decline of growth factors that comes with aging, also known as somatopause [6], reduce body fat and thus increase muscle and lean body mass [7], increase appetite [8], Alleviation of pathology related to beta-amyloid [9] , deeper and better sleep [10]

faster recovery times after muscle tear,  increased physical mass, and potentially some anti-aging benefits in test subjects,

 

Why You Should Buy MK-677 From Our Store?

If you’re looking  to buy MK677 (Ibutamoren) online, it may get a bit confusing due to all the possibilities available online. Sarmful.com is the best place to buy MK677 (Ibutamoren) online due to our consistently verifiable high quality products and superb customer service. professional bottling and packaging procedures, and extremely fast shipping. We also have MK677 (Ibutamoren) for sale in pure powder form. It is important to remember that not all companies advertising MK677 for sale are similar in both trustworthiness and quality. To buy MK677 from a random unknown website is risky, regardless of the price tag, as due to  having no information about their quality control processes. Sarmful proudly offers the highest quality MK677 for sale anywhere on the internet.

By choosing to buy SARMs at our store Sarmful.com you are investing in the highest quality ingredients, that means minimum 98% (and often higher) pure compounds tested and certified by accredited US third party labs- visit out tests page for more info.

More benefits:

  • Each Bottle includes a graduated 1mL glass pipette for convenient measurement.
  • SARMS are sold in glass bottles with UV resistance which minimizes degradation and BPA leaching from plastics.
  • Consistent dosing with less than 5% in variance in concentration.
  • We Bottle our SARMS in the US and send them directly from the US.
  • We pack, store and ship them in a securely way to avoid evaporation during storage and transit
  • Each bottle contains a seal for tamper proof avoidance.
  • Our SARMS are suspended in USP grade (the highest grade) PEG400
  • Transparent business methods without dodgy product descriptions and payment methods

These are just several of the claims-making us are confident we offer the best Ibutamoren for sale available on the market today.  Should you have any queries about our liquid MK-677 or powder MK-677 products, feel free to contact us and we’ll respond as soon as possible.

Benefits of MK-677

MK-677 has intrigued researchers with some of the potential benefits it has shown in subjects.

There have been many different studies that have shown lots of success in helping subjects increase muscle mass and recover faster between intense periods of physical activity. Similarly, MK-667 has exhibited considerable success in helping research subjects achieve fairly rapid fat tissue reduction. Some of the most exciting results have come with positive developments in some subjects' sleep patterns. MK-677 has been shown to increase the consistency of REM sleep which has resulted in much deeper and higher quality sleep.

There are also several intriguing developments with MK-677 as a potential anti-aging treatment. Studies have shown several common anti-aging properties, raising the possibility of a potential treatment for conditions such as Alzheimer's disease and dementia.

One study found that MK-677 boosted IGF-I and IGF-binding protein-3 (IGFBP-3) levels, and potentially could be used to counter somatotropic deficiency [1]. A different study found that 25mg per day of MK-677 increased muscle mass, bone mineral density and turnover, and osteoblast activity in older test subjects and improved their body composition, in addition to lower cholesterol levels while improving appetite [2]. Another study is currently at the preclinical stages of investigation for Growth hormone deficiency [5], Another controlled trial in healthy individuals ages 24 – 39 on a calorie-restricted diet demonstrated that MK677 improved significantly nitrogen retention. Meaning subjects maintained muscle mass even with less than sufficient protein consumption [8]. An animal study suggests that MK677 may be effective in reducing neurodegeneration, and neuroinflammation, and slowing other significant contributory factors for dementia and Alzheimer’s Disease [9]. The implications are that MK 677 may function as a preventative anti-aging agent- at least in animals. One more study on the effect of MK 677 on sleep showed a  decrease in REM latency and a 50% increase REM sleep in older individuals, as well as a 50% increase in stage 4 sleep and a 20% increase in REM sleep in younger individuals with the administration of MK677 [10].

MK-677 Half-Life

It's important to note that MK-677 has a fairly long 24-hour half-life.  This raises some concern that over-administration of MK-677 can overstimulate or desensitize the ghrelin receptor in the human brain.

Side Effects of MK-677

Anecdotally, MK-677 has several potential side effects including bloating, high blood pressure, increased appetite [3,4], joint swelling, and tingling on the paws or skin. As a result, many of the potential side effects are associated with high levels of growth hormone.

MK-677 should be used for research purposes only.

MK-677 Chemical Structure and Chemical Properties

Mk677 Chemical Structure

Mk677 Chemical Structure

  • Synonyms: MK-677, MK-0677, L-163,191, Oratrope, Ibutamoren, N-[1(R)-1,2-Dihydro-1-methanesulfonylspiro-3H-indole-3,4′-piperidin)-1′-yl]carbonyl-2-(phenylmethoxy)-ethyl-2-amino-2-methylpropanamide methanesulfonate
  • Empirical Formula: C27H36N4O5S
  • SMILES: O=S(C)(=O)N(C2)c1ccccc1C23CCN(CC3)C(=O)C(NC(=O)C(N)(C)C)COCc4ccccc4
  • International Chemical Identifier: InChI=1S/C27H36N4O5S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27/h4-12,22H,13-19,28H2,1-3H3,(H,29,33)/t22-/m1/s1
    Key:UMUPQWIGCOZEOY-JOCHJYFZSA-N

MK-677 (Ibutamoren) Solubility

  • Water Solubility: MK-677 is not soluble in water.
  • DMSO: soluble.
  • Ethanol: soluble
  • Propylene glycol: soluble

MK-677 properties

  • MK-677 smell: pure MK677 powder is odorless.
  • Appearance (raw powder): White crystalline powder.

Abuse Warning

SARMs should only be used under the direct supervision and direction of a trained and licensed medical doctor or a designated research authority. Sarmful strongly discourages the use of SARMs for performance enhancement in fields of various sports such as bodybuilding and achievement sports, etc.

S4 is an investigational compound still undergoing research and NOT yet FDA approved, nor it is a dietary supplement. Sarmful is solely a research chemical supplier specializing in sourcing and quality control. We are not medical doctors. Sarmful discourages strongly against “bro science” and peer consensus when making decisions about human health.

We do not encourage or condone consumer use of SARMs products, they are for research purposes only.

 

References and further read

  1. G Copinschi, A Van Onderbergen, M L’Hermite-Balériaux, C M Mendel, A Caufriez, R Leproult, J A Bolognese, M De Smet, M O Thorner, E Van Cauter, Effects of a 7-day treatment with a novel, orally active, GH secretagogue, MK-677, on 24-hour GH profiles, IGF 1, and adrenocortical function in normal young men, The Journal of Clinical Endocrinology & Metabolism, Volume 81, Issue 8, 1 August 1996, Pages 2776–2782, https://academic.oup.com/jcem/article/81/8/2776/2875610
  2. Murphy MG, Bach MA, Plotkin D, Bolognese J, Ng J, Krupa D, et al. Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group. J Bone Miner Res. 1999;14:1182–1188 https://pubmed.ncbi.nlm.nih.gov/10404019/
  3. Patchett AA, Nargund RP, Tata JR, Chen MH, Barakat KJ, Johnston DB, Cheng K, Chan WW, Butler B, Hickey G, et al. Design and biological activities of L-163,191 (MK-0677): a potent, orally active GH secretagogue. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7001-5. doi: 10.1073/pnas.92.15.7001. PMID: 7624358; PMCID: PMC41459.
  4. Meyer RM, Burgos-Robles A, Liu E, Correia SS, Goosens KA. A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear. Mol Psychiatry. 2014 Dec;19(12):1284-94. doi: 10.1038/mp.2013.135. Epub 2013 Oct 15. PMID: 24126924; PMCID: PMC3988273.
  5. Chapman IM, Pescovitz OH, Murphy G, Treep T, Cerchio KA, Krupa D, Gertz B, Polvino WJ, Skiles EH, Pezzoli SS, Thorner MO. Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults. J Clin Endocrinol Metab. 1997 Oct;82(10):3455-63. doi: 10.1210/jcem.82.10.4297. PMID: 9329386.
  6. Smith RG, Sun Y, Jiang H, Albarran-Zeckler R, Timchenko N. Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Ann N Y Acad Sci. 2007 Nov;1119:147-64. doi: 10.1196/annals.1404.023. PMID: 18056963.
  7. Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE Jr, Clasey JL, Heymsfield SB, Bach MA, Vance ML, Thorner MO. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008 Nov 4;149(9):601-11. doi: 10.7326/0003-4819-149-9-200811040-00003. PMID: 18981485; PMCID: PMC2757071.
  8. Murphy MG, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. J Clin Endocrinol Metab. 1998 Feb;83(2):320-5. doi: 10.1210/jcem.83.2.4551. PMID: 9467534.
  9. Jeong YO, Shin SJ, Park JY, Ku BK, Song JS, Kim JJ, Jeon SG, Lee SM, Moon M. MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease. Int J Mol Sci. 2018 Jun 18;19(6):1800. doi: 10.3390/ijms19061800. PMID: 29912176; PMCID: PMC6032329.
  10. Copinschi G, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. 1997 Oct;66(4):278-86. doi: 10.1159/000127249. PMID: 9349662.
MK677

65.99

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