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S4 (Anadrine)

An older generation SARM developed by GTX inc.

59.99

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📄 Short Description

Are you looking for S4 SARM for sale? (Anadrine) at our store, you can easily buy S4 SARM online. Anadrine is a less common SARM than other SARMs like Ostarine or LGD4033.

  • Active Ingredient: S4 (Anadrine)
  • Strength: 50mg/ml
  • Each Bottle Contains: 30ml

✅ 3rd-Party Lab Tests  

Lab test date: 12/06/2023
Lab: Colmaric Analyticals
Speficiation: >98%
Result: 101.3%

Overview of Our S4 SARM for Sale

Synonyms Acetamidoxolutamide; Androxolutamide; GTx-007; S-4
Concentration 50mg per ml
Solvent USP Grade Polyethylene Glycol 400
Molar Mass 441.363 g·mol−1
CAS 401900-40-1
Chemical Formula C19H18F3N3O6

This product is for laboratory research purposes only and is not approved by the FDA for human use. S4 is NOT a dietary supplement. Any information about its use in this product description refers to clinical research only. By ordering from this site, you agree to our terms of service.

Additional information about our S4 SARM (Anadrine)

SARMs (Selective Androgen Receptor Modulators) are a relatively new class of drugs that have increased in relevance in recent years with more clinical trials. Among the most interesting SARMs is S4 commonly known as Andarine, which is the original SARM that led to such wide research interest in all other similarly acting compounds today known as SARMS. In the early days, scientists discovered that S4 despite the molecular difference in the appearance of this molecule compared to steroids, surprisingly still activated the selective androgen receptors in the body, more so especially the receptors in the connective tissue, ligaments, bones, and muscles. favoring these areas over breasts, prostate, and scalp by a rather complex mechanism of molecular selective affinity binding. Surprisingly enough, is that even though S4 (Andarine) considered to be the grandfather of all SARM, S4 (Andarine) is still considered by researchers to be the best SARM for losing body fat.

Rodent studies specifically on lab rats demonstrate clear bone health improvements directly linked to the amount of S4 administered. For example, a study in which 1.6mg/kg body weight was administered showed significant improvement in body composition, lean mass, and bone mineral density [1]. in another study, the administering of 3mg/kg/day demonstrated a significant increase in bodily mass too [2]. Last but not least, a study [3] conducted on an ovariectomized rat model for osteoporosis 3 and 10mg/kg/day was given to the rat for 8 weeks, showing bone mineral density and body mass in both groups improvements, in addition to decreased body fat and increased cortical content.  Primary culture of bone marrow osteoprogenitor cells demonstrated that Andarine was more anabolic than DHT for promoting osteoblast formation, demonstrating the compound's anabolic potential in bone tissue even further [1, 3].

Another study [4], has shown that S4 can result in prostate weight decrease, achieved in the same levels as using 5mg/kg finasteride, rather than without levator and muscle effects (an indicator of relative androgenicity). This may suggest that SARMS  may hold the secret for such undesirable prostate growth situations, even though SERMS are considered by many to be the ideal option  for reducing breast tissue cancers

Why You Should Buy S4 SARM From Our Store?

If you’re looking to buy S4 (Andarine) online, it may get a bit confusing due to all the possibilities available online. Sarmful.com is the best place to buy S4 (Andarine) online due to our consistently verifiable high-quality products and superb customer service. professional bottling and packaging procedures, and extremely fast shipping. We also have S4 (Andarine) for sale in pure powder form. It is important to remember that not all companies advertising S4 for sale are similar in both trustworthiness and quality. To buy S4 from a random unknown website is risky, regardless of the price tag, as due to  having no information about their quality control processes. Sarmful proudly offers the highest quality S4 for sale anywhere on the internet.

By choosing to buy SARMs at our store Sarmful.com you are investing in the highest quality ingredients, that means minimum 98% (and often higher) pure compounds tested and certified by accredited US third party labs- visit out tests page for more info.

More benefits:

  • Each Bottle includes a graduated 1mL glass pipette for convenient measurement.
  • SARMS are sold in glass bottles with UV resistance which minimizes degradation and BPA leaching from plastics.
  • Consistent dosing with less than 5% in variance in concentration.
  • We Bottle our SARMS in the US and send them directly from the US.
  • We pack, store and ship them in a securely way to avoid evaporation during storage and transit
  • Each bottle contains a seal for tamper proof avoidance.
  • Our SARMS are suspended in USP grade (the highest grade) PEG400
  • Transparent business methods without dodgy product descriptions and payment methods

These are just several of the claims us confident we offer the best Andarine for sale available on the market today.  Should you have any queries about our liquid S4 or powder S4 products, feel free to contact us and we’ll respond as soon as possible.

S4 Half-life

S4 has a half-life of only 4 hours, which means that it is broken down and eliminated from the body at a rate of 50% every 4 hours. This makes it important to be cautious with S4 in animals, as the potency creates potential risks of overdose if too much is given at once.

The History of S4

The development of S4 began in 2001 when GTX, Inc. screened a library of over 1600 compounds and identified bicalutamide as a potent androgen receptor antagonist. This led to the development of S4 (also known as GTx-024), a nonsteroidal selective androgen receptor modulator (SARM) with improved potency and reduced side effects compared to bicalutamide.

In preclinical studies, S4 was found to improve muscle mass and strength and reduce fat mass, while causing only a fraction of the side effects seen with testosterone replacement therapy. In the Phase II clinical trial, S4 was found to be safe and well tolerated and resulted in a significant increase in muscle mass and strength relative to the placebo group. A Phase III clinical trial is currently underway to evaluate the safety and efficacy of S4 for the treatment of muscle wasting in patients with cancer.

S4 Benefits

Andarine (S4) is a selective androgen receptor modulator (SARM) that has been shown to have some potential therapeutic applications, including the treatment of benign prostatic hyperplasia, muscle wasting, and osteoporosis.

S4 Side Effects

Like all SARMs, S4 exhibits a favorable safety profile and is generally well tolerated from anecdotal reports. at higher quantities, the primary side effects with S4 are yellow-tinged or altered vision and suppression of testosterone.

These side effects are typically mild and transient and can be minimized by administering S4 on an intermittent basis.

S4 (Anadrine) Chemical Structure and Chemical Properties

S4 SARM Chemical Structure

S4 SARM Chemical Structure

  • Synonyms: (S)-3-(4-Acetylaminophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propionamide, Acetamidoxolutamide; Androxolutamide; GTx-007; S-4
  • Empirical Formula: C19H18F3N3O6
  • SMILES:
  • FC(F)(F)c1cc(ccc1[N+]([O-])=O)NC(=O)[C@@](O)(COc2ccc(cc2)NC(=O)C)C
  • International Chemical Identifier:
  • InChI=1S/C19H18F3N3O6/c1-11(26)23-12-3-6-14(7-4-12)31-10-18(2,28)17(27)24-13-5-8-16(25(29)30)15(9-13)19(20,21)22/h3-9,28H,10H2,1-2H3,(H,23,26 (H,24,27)/t18-/m0/s1 Key:YVXVTLGIDOACBJ-SFHVURJKSA-N 
  • CAS: 401900-40-1 

S4 SARM (Anadrine) Solubility

S4 is not soluble in water but can be solved in other solvents.

  • Water Solubility: S4 SARM is not soluble in water.
  • DMSO: soluble.
  • Ethanol: soluble
  • Propylene glycol: soluble.
  • PEG-400: soluble.

Other properties

  • S4 SARM smell: Pure Anadrine is odorless.
  • Appearance (raw powder): Yellow fine powder.

Takeaways

S4 SARM is becoming more and more relevant. It is proven to increase muscle mass, burn fat, and improve overall health in animal subjects during clinical trials. [1,2,3,4]

The compound is still in its infancy and there needed more studies and clinical trials are needed to better determine its profile.

Abuse Warning

SARMs should only be used under the direct supervision and direction of a trained and licensed medical doctor or a designated research authority. Sarmful strongly discourages the use of SARMs for performance enhancement in fields of various sports such as bodybuilding and achievement sports, etc.

S4 is an investigational compound still undergoing research and NOT yet FDA approved, nor it is a dietary supplement. Sarmful is solely a research chemical supplier specializing in sourcing and quality control. We are not medical doctors. Sarmful discourages strongly against “bro science” and peer consensus when making decisions about human health.

We do not encourage or condone consumer use of SARMs products, they are for research purposes only.

References and further read

1. Hott JL, Borkman RF (November 1989). “The non-fluorescence of 4-fluorotryptophan”. The Biochemical Journal. 264 (1): 297–9. doi:10.1124/jpet.102.040840. PMC 1133577. PMID 2604714 https://europepmc.org/article/med/2604714

2. Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, Miller DD, Dalton JT. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005;146:4887–4897. https://europepmc.org/article/med/17063395

3. Kearbey JD, Gao W, Miller DD, Dalton JT. Selective androgen receptor modulators inhibit bone resorption in rats. AAPS PharmSci. 2003;5 https://academic.oup.com/endo/article/146/11/4887/2500134

4. Gao W, Kearbey JD, Nair VA, Chung K, Parlow AF, Miller DD, Dalton JT. Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology. 2004;145:5420–5428 https://www.auajournals.org/doi/10.1016/S0022-5347%2801%2968993-6

Anadrine

59.99

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