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BPC stands for Body Protection Compound-157 (BPC-157). It is a synthetically produced peptide derivative of a protein found naturally in the human gastric juice in the GI tract called the Body Protection Compound (BPC). Even though it is a smaller peptide consisting of 15 amino acids in total, BPC-157 has been found to have many of the same properties as its parent bigger molecule, these are wound healing, blood vessel growth, general gut health, and nitric oxide generation assistance.
BPC-157 also was found to modulate the immune system function, help with gene expression, and hormone regulation in the gastrointestinal nervous system as well as the coagulation cascade [2]. Most data on the BPC 157 peptide is derived from animal models and limited data is available from clinical trials. below are some studies conducted on the compound.
In connective tissue injuries, a lack of blood flow can hinder how quickly fibroblasts and other wound-repairing cells are carried to the injury site limiting tendon healing. The same study as above have shown positive outcomes in animal with regard to treating tendon, ligament, bone, and skin burns [2]. In this same study, done on rats, BPC-157 has been shown to improve the growth factor in collateralization and density of fibroblasts around tendons, ligaments, muscle tissue, and bones after injuries occur, while promoting vascular growth [2]
Collateral blood vessel growth is also an area of growing interest with respect to research on BPC-157 since vascular growth may significantly augment the wound-healing process in tissues that are otherwise limited by low blood supply, like ligament injuries.
BPC 157 has also shown effectiveness in counteracting corticosteroid-impaired muscle healing [12, 13].
BPC 157 helps to reverse damage caused to cells by encouraging the fibroblast cells to multiply and migrate more easily while improving the synthesis of proteins such as collagen, fibrin, and elastin. Similar effects of the BPC-157 peptide have been demonstrated in endothelial cells, which are responsible for lining the blood vessels [1-3].
A handful of studies conducted on rat and chicken embryos found that BPC-157 significantly boosts the production of new blood vessels and the growth of collateral blood vessels, suggesting that BPC-157 may one day be used to treat stroke and heart attack, patients. [4-8]. Further research is required on the cyto-cellular protective effects of the BPC 157 compound.
One animal study has shown that BPC-157 functions as an antioxidant agent and may protect against oxidative stress effects. In a research study, when BPC-157 peptides were used on rats, they experienced reduced levels of nitric oxide and malondialdehyde, two indicators for tissue damage due to free radicals [3]. BPC-157 may exhibit similar effects within mammal gastric juices but this is to be determined in the future by clinical trials.
The above statement is further supported by an additional study that has shown that BPC-157 can lower the production of reactive oxygen species in the gastrointestinal tract tissue. It was shown that a modified form of lactococcus lactis bacteria increased levels of BPC 157 in cell culture [9], indicating that BPC 157 may play a significant role in probiotic modulation of gastrointestinal wound healing.
As written above, since BPC 157 is a derivative of a natural compound in human gastric juices, it is of particular interest in clinical research with regard to gut health and for treating inflammatory bowel disease, leaky gut, and stomach ulcer conditions. BPC 157 peptide plays a role in the brain-gut axis and naturally improves and shields the mucosal barrier of the digestive tract. This form of tissue fix is what it is currently renowned for [10]. In a study of rat model of esophagitis untreated for 12-20 months, when given administered right into the stomach, BPC 157 peptide therapy instantaneously recovered disturbed lower esophageal and pyloric sphincter pressure [10] This suggests an accelerated healing process resulting from BPC 157 administration. BPC 157 peptide also antagonized some alcohol effects, including acute and chronic intoxication [10].
In another study done on rats with short-bowel syndrome over 4 weeks, BPC 157 therapy yielded a significant increase in weight beyond preoperative values when given orally or parentally. Also, villus height, crypt depth and muscle thickness increased dramatically with this in rats treated with BPC157 [11-13]. Rats with ischemia and colitis in another study experienced stark improvements in blood flow and local nitric oxide utilization after given BPC 157, with virtually no remaining lesions and only minimal adhesions after only 10 days of treatment [4]. Of course, more research is needed on the effects of BPC 157 on Crohn’s disease, gastric ulcers, and other gastrointestinal pathologies.
SARMs should only be used under the direct supervision and direction of a trained and licensed medical doctor or a designated research authority. Sarmful strongly discourages the use of SARMs for performance enhancement in fields of various sports such as bodybuilding and achievement sports, etc.
S4 is an investigational compound still undergoing research and NOT yet FDA approved, nor it is a dietary supplement. Sarmful is solely a research chemical supplier specializing in sourcing and quality control. We are not medical doctors. Sarmful discourages strongly against “bro science” and peer consensus when making decisions about human health.
We do not encourage or condone consumer use of SARMs products, they are for research purposes only.
1. Drmic D, Samara M, Vidovic T, Malekinusic D, Antunovic M, Vrdoljak B, Ruzman J, Milkovic Perisa M, Horvat Pavlov K, Jeyakumar J, Seiwerth S, Sikiric P. Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine. World J Gastroenterol. 2018 Dec 28;24(48):5462-5476. doi: 10.3748/wjg.v24.i48.5462. PMID: 30622376; PMCID: PMC6319139.
2. Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther. 2015 Apr 30;9:2485-99. doi: 10.2147/DDDT.S82030. PMID: 25995620; PMCID: PMC4425239.
3. Amic F, Drmic D, Bilic Z, Krezic I, Zizek H, Peklic M, Klicek R, Pajtak A, Amic E, Vidovic T, Rakic M, Milkovic Perisa M, Horvat Pavlov K, Kokot A, Tvrdeic A, Boban Blagaic A, Zovak M, Seiwerth S, Sikiric P. Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine. World J Gastroenterol. 2018 Dec 21;24(47):5366-5378. doi: 10.3748/wjg.v24.i47.5366. PMID: 30598581; PMCID: PMC6305534.
4. Duzel A, Vlainic J, Antunovic M, Malekinusic D, Vrdoljak B, Samara M, Gojkovic S, Krezic I, Vidovic T, Bilic Z, Knezevic M, Sever M, Lojo N, Kokot A, Kolovrat M, Drmic D, Vukojevic J, Kralj T, Kasnik K, Siroglavic M, Seiwerth S, Sikiric P. Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights. World J Gastroenterol. 2017 Dec 28;23(48):8465-8488. doi: 10.3748/wjg.v23.i48.8465. PMID: 29358856; PMCID: PMC5752708.
5. Vukojević J, Siroglavić M, Kašnik K, Kralj T, Stanćić D, Kokot A, Kolarić D, Drmić D, Sever AZ, Barišić I, Šuran J, Bojić D, Patrlj MH, Sjekavica I, Pavlov KH, Vidović T, Vlainić J, Stupnišek M, Seiwerth S, Sikirić P. Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157. Vascul Pharmacol. 2018 Jul;106:54-66. doi: 10.1016/j.vph.2018.02.010. Epub 2018 Mar 3. PMID: 29510201.
6. Drmic D, Kolenc D, Ilic S, Bauk L, Sever M, Zenko Sever A, Luetic K, Suran J, Seiwerth S, Sikiric P. Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME. World J Gastroenterol. 2017 Aug 7;23(29):5304-5312. doi: 10.3748/wjg.v23.i29.5304. PMID: 28839430; PMCID: PMC5550779.
7. Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JS. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017 Mar;95(3):323-333. doi: 10.1007/s00109-016-1488-y. Epub 2016 Nov 15. PMID: 27847966.
8. Grabarevic Z, Tisljar M, Artukovic B, Bratulic M, Dzaja P, Seiwerth S, Sikiric P, Peric J, Geres D, Kos J. The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks. J Physiol Paris. 1997 May-Oct;91(3-5):139-49. doi: 10.1016/s0928-4257(97)89478-8. PMID: 9403788.
9. Škrlec K, Ručman R, Jarc E, Sikirić P, Švajger U, Petan T, Perišić Nanut M, Štrukelj B, Berlec A. Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities. Appl Microbiol Biotechnol. 2018 Dec;102(23):10103-10117. doi: 10.1007/s00253-018-9333-6. Epub 2018 Sep 6. PMID: 30191288.
10. Sikiric P, Seiwerth S, Brcic L, Blagaic AB, Zoricic I, Sever M, Klicek R, Radic B, Keller N, Sipos K, Jakir A, Udovicic M, Tonkic A, Kokic N, Turkovic B, Mise S, Anic T. Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response. Inflammopharmacology. 2006 Dec;14(5-6):214-21. doi: 10.1007/s10787-006-1531-7. PMID: 17186181.
11. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Vrcic H, Sebecic B. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Curr Pharm Des. 2011;17(16):1612-32. doi: 10.2174/138161211796196954. PMID: 21548867.
12. Pevec D, Novinscak T, Brcic L, Sipos K, Jukic I, Staresinic M, Mise S, Brcic I, Kolenc D, Klicek R, Banic T, Sever M, Kocijan A, Berkopic L, Radic B, Buljat G, Anic T, Zoricic I, Bojanic I, Seiwerth S, Sikiric P. Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Med Sci Monit. 2010 Mar;16(3):BR81-88. PMID: 20190676.
13. Unveiling the Wolverine Peptide: Exploring its Potential for Healing and Regeneration. Peptide Information (2023)
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