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Are you looking for Cardarine for sale? (GW501516) at our store, you can easily buy Cardarine (GW501516) online. Cardarine is a PPARδ receptor agonist and has shown to help with endurance.
| Synonyms | Cardarine, GW501516, Endurobol |
| Concentration | 20mg per ml |
| Solvent | USP Grade Polyethylene Glycol 400 |
| Molar Mass | 453.49 g·mol−1 |
| CAS | 317318-70-0 |
| Chemical Formula | C21H18F3NO3S2 |
This product is for laboratory research purposes only and is not approved by the FDA for human use. Cardarine is NOT a dietary supplement. Any information about its use in this product description refers to research only. By ordering from this site, you agree to our terms of service.
Cardarine has become a widely studied synthetic compound It has become a focal point for many researchers with studies focused on weight loss and managing health conditions.
Cardarine, also commonly known as GW501516 and less commonly Endurobol, GW1516 and GSK-516 is a PPAR (peroxisome proliferator-activated receptor) agonist and ligand-activated transcription factor that specifically and uniquely binds to the receptors in skeletal muscle tissue and body fat and then causes the skeletal muscle cells towards preferential lipid utilization and fat burning processes. PPAR is also related to inflammation, glucose homeostasis, cell proliferation, differentiation, and apoptosis mechanisms, suggesting a potential anti-aging effects related of the PPAR agonists. Interestingly enough, PPAR are located in highest concentration in tissues which contain high metabolic rates such as the skeletal muscle, intestine, liver, heart, and kidney [1]. Surprisingly, even though as a PPAR, it shares certain commonalities with SARMs, Cardarine is often wrongly classified as a selective androgen receptor modulator (SARM) but differs from SARMs in a few important ways. Cardarine does not affect androgen receptors or alter testosterone levels however it does have a key involvement in energy metabolism.
GW501516 displays high affinity (Ki = 1 nM) and potency for PPARδ with over 1,000-fold selectivity over PPARα and PPARγ [2]. The binding of Cardarine to the PPARδ recruits the coactivator PGC-1α. The PPARδ/coactivator complex in thus upregulates the effects of protein molecules involved in energy expenditure [3]. By activating AMP-activated protein kinase, Cardarine is widely believed to provide a broad range of experimental effects which are being researched such as increases fatty acid oxidation and promotes fat loss, Better HDL cholesterol (“good cholesterol”) and LDL cholesterol (“bad cholesterol”) levels, Increases endurance , reduces inflammation and insulin resistance while improves glucose tolerance.
Research data indicates that PPAR activity maintains glucose for use in tissues such as the brain while promoting the mobilization of fatty acids for muscular endurance [4]. PPAR has also been observed playing an important role in body temperature regulation, inflammation mediation, mitochondrial respiration, keratinocyte differentiation, and skin and muscle repair processes. Molecular analyses revealed that PPAR regulates the expression of genes linked to contractile proteins, lipid oxidation, and mitochondrial biogenesis [4].
These effects of PPAR are observed in particular during fasting or intermittent fasting, when free fatty acids are released into the blood cycle. One study in PPAR-null mice shown that the lack of PPAR causes elevated free fatty acids during intermittent fasting, lipid accumulation in the liver and heart, low blood sugar, low body temperature, ketones in the urine, and even possibly a premature death [5]. Mice usually though adapt to high level of free fatty acid during fasting through induction of cardiac and hepatic PPAR genes that improve fatty acid uptake and oxidation [6].
All these above described processed and/or benefits and side effects of GW501516 however, have not been confirmed or approved by the Food and Drug Administration (FDA), thus it should be used for research purposes only.
If you’re looking to buy GW501516 (Cardarine) online, it may get a bit confusing due to all the possibilities available online. Sarmful.com is the best place to buy GW501516 (Cardarine) online due to our consistently verifiable high quality products and superb customer service. professional bottling and packaging procedures, and extremely fast shipping. We also have GW 501516 (Cardarine) for sale in pure powder form. It is important to remember that not all companies advertising Cardarine for sale are similar in both trustworthiness and quality. To buy Cardarine from a random unknown website is risky, regardless of the price tag, as due to having no information about their quality control processes. Sarmful proudly offers the highest quality Cardarine for sale anywhere on the internet.
By choosing to buy SARMs at our store Sarmful.com you are investing in the highest quality ingredients, that means minimum 98% (and often higher) pure compounds tested and certified by accredited US third party labs- visit out tests page for more info.
More benefits:
Cardarine is a research chemical that was first developed in the early 1990s by GlaxoSmithKlein with its last clinical study ending in 2009. It was originally studied in mice as a potential treatment for diabetes, but it was later discovered that Cardarine had other potential uses.
While research in humans is severely lacking, some studies in mice have shown that Cardarine may help with weight loss and improve blood lipids. Additionally, Cardarine may have benefits for diabetes and obesity.
A number of animal studies have been conducted thus far and demonstrate Cardarine’s ability to enhance certain physiological processes related to energy metabolism and potential improvements in blood lipids.
One study in mice shown that Cardarine promoted fatty acid oxidation and fat burning in skeletal muscle tissue and alleviates metabolic syndrome [7]. A different study demonstrated that peroxisome proliferator-activated receptors can markedly improved running endurance in Kunming mice [8]. Another study conducted on mice revealed that PPARs augment exercise endurance by preventing exhaustion of glucose (“hitting the wall syndrome”) [9]. Another interesting study on obese rhesus monkeys demonstrated that Cardarine improved high-density lipoprotein (HDL, good cholesterol) and reduced very low density lipoprotein (VLDL), indicating potential cardioprotective effects from Cardarine [9]. Interestingly enough, two separate phase II clinical studies concluded positive effects of Cardarine molecules on obesity, diabetes, dyslipidemia, and cardiovascular disease, as well as suppression in macrophage-derived inflammation [10, 11]. Last but not least one study in rats that were on a high fructose diet shown that GW501516 reduced bad inflammation markers, especially in the liver tissue, and increased the expression of genes that regulate beta-oxidation [12]
There were no notable side effects reported based on the human studies performed, which may be due to limited study durations or the small doses used in humans.
Cardarine is much different than many other research chemical as it does not stimulate the nervous system to trigger fat loss. This means that its known side effects profile are much different than many other research chemicals and as of now there are no well-known common ones. GW501516 is not known to cause androgenic side effects like anabolic androgenic steroids, data extracted from rats indicates that doses of 3mg/kg/day (180-240mg per day in the average 60-80kg adult), significantly increased than those used in mammalian trails, resulted in cancer developing quickly in several locvations[13]. Anecdotal data from the world wide web indicates very little of noticeable side effects but more research is necessary to determine the overall safety profile of Cardarine.
Cardarine is sold as a research compound in most health supplement specialty stores online.
Cardarine has a long history with cancer research. GSK originally developed it as a potential cancer treatment drug. Since it has been studied as a potential cause of increased cancer incidence. These findings have been fairly ambiguous but they are ongoing and worth monitoring as their results become more statistically significant.
Cardarine is not legally allowed to be sold as a supplement. Hence, you won’t find Cardarine pills for sale in the US, as they are prohibited for human consumption.
Often compared because Cardarine and Stenabolic are both agonists. However, Cardarine is a PPAR versus Stenabolic which is a REV-ERB agonist.
Cardarine in research studies has shown much more potential as a compound that builds endurance in its subjects.
Stenabolic is more expensive than Cardarine, but it also has a longer half-life.
Cardarine is much stronger and more potent on a per-milligram basis.
Cardarine Chemical Structure
Cardarine is a compound that has been around for 15 years and has seen a lot of research over the years. There are still lots of questions about how Cardarine works and what its long-term side effects might be.
SARMs should only be used under the direct supervision and direction of a trained and licensed medical doctor or a designated research authority. Sarmful strongly discourages the use of SARMs for performance enhancement in fields of various sports such as bodybuilding and achievement sports, etc.
S4 is an investigational compound still undergoing research and NOT yet FDA approved, nor it is a dietary supplement. Sarmful is solely a research chemical supplier specializing in sourcing and quality control. We are not medical doctors. Sarmful discourages strongly against “bro science” and peer consensus when making decisions about human health.
We do not encourage or condone consumer use of SARMs products, they are for research purposes only.
€59.99
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