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Are you Looking for RAD140 for sale? at our store, you can easily buy RAD140 liquid. RAD140 is considered a very common SARM, which has shown to be a potent anabolic agent in clinical research.
| Synonyms | Testolone |
| Concentration | 15mg per ml |
| Solvent | USP Grade Polyethylene Glycol 400 |
| Molar Mass | 393.83 g·mol−1 |
| CAS | 1182367-47-0 |
| Chemical Formula | C20H16ClN5O2 |
This product is for laboratory research purposes only and is not approved by the FDA for human use. RAD140 is NOT a dietary supplement. Any information about its use in this product description refers to clinical research only. By ordering from this site, you agree to our terms of service.
RAD140, also commonly known as Testolone, is one of several novel selective androgen receptor modulators (SARMs) that was initially studied and tested as an alternative to TRT (testosterone replacement therapy). It should not be interchanged with RAD 150, Testolone also known as TLB 150 which is an esterified form of the same compound. As with other SARMs, RAD140 binds directly and selectively to the androgen receptors (AR) thus it does not produce androgenic effects as similar substances like testosterone DHT or other anabolic compounds do.
A study on male monkeys checked the anabolic effects after 28 days of RAD 140 at three different dosages of 0.01mg/kg, 0.1mg/kg, and 1mg/kg per day. RAD 140 demonstrated an excellent affinity for AR (Ki = 7 nM), higher even than DHT and most anabolic steroids. As general knowledge, the affinity for the androgen receptor (AR) for Testosterone in a recent preclinical model was 29 nM, and 10 nM for DHT. In the same study, an average weight gain of 10% was observed in both the 0.1mg/kg/day group and the 1mg/kg/day group, demonstrating a quantity response curve that has peaked and showed no additional benefit with increased dosages. Also, an effect on body fat mass in either group was not established consistently, nonetheless, it did show muscle mass increased in the 0.1 and 1mg/kg/day groups. No noteworthy increases in liver enzymes or prostate weight were reported in either test group implying a high level of selectivity for androgen receptors (AR) in muscle tissue [1].
By choosing to buy SARMs at our store Sarmful.com you are investing in the highest quality ingredients, that means minimum 98% (and often higher) pure compounds tested and certified by accredited US third party labs- visit out tests page for more info.
More benefits:
RAD140 was developed in 2010 as a SARM that selectively targets and blocks DHT without affecting testosterone. Initially, Radius Health developed the compound. Radius Health is a health care company specializing in the development and commercialization of novel therapies in the field of musculoskeletal health.
RAD140 has shown potential as a treatment option for conditions revolving around bone loss and muscle wasting. As a result, in 2020 it was licensed to Ellipses Pharmaceuticals to try and further its development for some of these use cases.
In a study conducted in 2014 which investigated the neuroprotective benefits of RAD 140 on cultured neurons and male rats that were lesioned with kainate, divided into two parts (in vitro and another in vivo through animal testing). The in vitro results showed that RAD 140 was able to prevent cell death and restore mitochondrial membrane potential, demonstrating that it may offer neuroprotection benefits much like those of testosterone and other androgens. The in vivo phase of the same study checked the efficacy of RAD 140 on male rats with kainate-induced seizures and showed a significant reduction in seizures. Overall, this study has shown that RAD140 is capable of providing some neuroprotection both in vitro and in vivo [2].
A different study on rats in which a test group was treated with 3 mg/kg RAD140 was able to mimic the same level of muscle tissue growth as the group treated with a 3 times lower dosage of 1 mg/kg Testosterone, with about half of the androgenic activity in the prostate. it also found that RAD140 had neuroprotective effects that may combat Alzheimer’s disease and similar disorders, and may even surprisingly be safer than conventional testosterone therapy [3].
In some other studies, different androgens have demonstrated clinical significance in preventing neuronal death and improving cognitive function in Alzheimer’s Disease (AD), mainly by a nongenomic mechanism of the AR. Rapid phosphoinositide 3-kinase/Akt signaling, which is activated by androgens, regulates the expression of proteins closely linked to the death of cells such as bax, seladin 1, survivin, XIAP, and bcl-xl [8]. Interestingly enough, these androgens can also maintain the health and wholeness of neurons thus improving boost function [9]. This same study also demonstrated that Aβ impairs synaptic structure and function of hippocampal neurons which can be reversed by androgen administration resulting in improved cognitive function in animal models with Alzheimer’s Disease. Sadly though, the exact mechanisms are not yet fully understood, but androgen’s action of inhibiting Aβ-induced apoptosis appears to play a significant role [9].
A study conducted not too long ago in 2017 investigated the effects of RAD 140 on active cells of breast cancer. This study checked the efficacy of RAD140 in stopping the growth of breast cancer cells that were positive for both androgen receptors (ARs) and estrogen receptors (ERs). The study results demonstrated that in both in vivo and in vitro models of AR/ER breast cancer, RAD140 was able to significantly diminish the growth and spread of metastases of active breast cancer cells without disrupting their regular cell cycle, indicating it may be a promising therapy for treating such cancers types in the future [4]. Furthermore, the same study also demonstrated that RAD140 had specific different mechanisms of action from those of anti-estrogens and aromatase inhibitors, which implies that it could provide an additional therapeutic approach to treating hormone-sensitive breast cancers. All in all, this study has shown that RAD140 could be a potential option for AR/ER-positive breast cancer but more data is needed to determine its safety relative to other methods utilized at this time.
RAD 140 does not have the same side effect profile as some comparable products. However, it has been known to cause a few side effects in some subjects. These can include increased aggression, hormonal disorders, nausea, headache, acne, and hair loss.
One study from 2010 found that after 28 days of testing RAD140, testosterone levels in all three test groups was suppressed to approximately 200−300 ng/dL, with similar suppression outcomes in all groups. Although testosterone levels were significantly different for only the 0.01 mg/kg group (p < 0.05) [6].
Another study conducted on a single case only indicated drug-induced liver injury following after 11 months of the use of an anti-depressant, as well as intermittent use of RAD 140 and LGD-4033. The problems of this study however are the fact that it includes only one test subject (no control group), 11 months of consistent antidepressant use, the quality and quantity of SARMs used were not monitored, and additional comorbidities were not investigated [7]. Several other case studies exist indicating the potential for selective androgen receptor modulators to contribute to liver injury but none involve a significant group sample size or test controls to date, thuss hard to draw any meaningful conclusion.
In rat studies, there were some slight changes in liver enzymes that were not considered to be clinically significant. Overall, studies in rats have shown that RAD 140 appears to be safer than testosterone replacement therapy.
The half-life of RAD 140 is about 44.7 hours [5], meaning that a single test keeps its effects going the entire day-2 days. This makes it one of the longer-lasting SARMs out there.
RAD 140 is available for sale as a medical research compound at specialty retailers that sell other types of SARMs.
RAD140 Chemical Structure
RAD 140 has been shown in studies to build muscle mass in primates with less of a side effect profile than most other SARMs. It is still a relatively new compound and more research is needed. Its research for use as an androgen replacement therapeutic could produce some interesting breakthroughs in upcoming animal lab experiments.
SARMs should only be used under the direct supervision and direction of a trained and licensed medical doctor or a designated research authority. Sarmful strongly discourages the use of SARMs for performance enhancement in fields of various sports such as bodybuilding and achievement sports, etc.
S4 is an investigational compound still undergoing research and NOT yet FDA approved, nor it is a dietary supplement. Sarmful is solely a research chemical supplier specializing in sourcing and quality control. We are not medical doctors. Sarmful discourages strongly against “bro science” and peer consensus when making decisions about human health.
We do not encourage or condone consumer use of SARMs products, they are for research purposes only.
$65.99
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